SCHEMBL860016

SCHEMBL860016

Sc1nc2cc(Cl)ccc2o1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.61
CYP1A2 P05177 2/20 0.61
MAPT P10636 1/20 0.61
THRB P10828 1/20 0.61
ALOX15 P16050 1/20 0.61
MAPK1 P28482 1/20 0.61
PSMB8 P28062 1/20 0.56
SMN1; SMN2 Q16637 3/20 0.54
CASP3 P42574 2/20 0.54
SENP7 Q9BQF6 2/20 0.54
SENP6 Q9GZR1 2/20 0.54
KDM4E B2RXH2 5/20 0.51
ALDH1A1 P00352 3/20 0.51
HPGD P15428 2/20 0.51
NFKB1 P19838 1/20 0.51
NFKB2 Q00653 1/20 0.51
RELA Q04206 1/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
NPC1 O15118 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29593887 1.00 LMNA (0.61) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL17763531 0.84 SMN1; SMN2 (0.54) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL3062851 0.84 PIK3CG (0.61) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL11063958 0.82 PIK3CG (0.59) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL1672481 0.79 LMNA (0.66) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL135052 0.76 RAB9A (0.58) LMNAMAPTSMN1; SMN2CASP3SENP7
SCHEMBL4454889 0.76 MPO (0.45) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL9188510 0.76 RAB9A (0.58) CYP1A2MAPTSMN1; SMN2CASP3SENP7
SCHEMBL29593303 0.76 MPO (0.45) LMNACYP1A2MAPTTHRBALOX15
SCHEMBL2548822 0.76 ESR1 (0.58) MAPTMEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116005457-B Gel-assisted PBO fiber surface nondestructive treatment method 浙江工业大学 2025-05-02 CN claimed
CN-118948963-A Preparation method of low-sugar astragalus mongholicus pulse-activating drink 江西和盈药业有限公司 2024-11-15 CN claimed
CN-114874152-B Synephrine benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof 西南大学 2024-02-02 CN claimed
CN-116005457-A Gel-assisted PBO fiber surface nondestructive treatment method 浙江工业大学 2023-04-25 CN claimed
CN-115703737-A Hydroxypyridones compounds and application thereof as antibiotic sensitizer for overcoming drug resistance of bacterial biofilm 暨南大学 2023-02-17 CN claimed
CN-114874152-A Octylene benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof 西南大学 2022-08-09 CN claimed
US-12613191-B2 Multiplexed Raman molecular imaging UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2026-04-28 US disclosed
CN-116005457-B Gel-assisted PBO fiber surface nondestructive treatment method 浙江工业大学 2025-05-02 CN disclosed
US-20250051319-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS AUGUSTINE THERAPEUTICS (BE) 2025-02-13 US disclosed
CN-118948963-A Preparation method of low-sugar astragalus mongholicus pulse-activating drink 江西和盈药业有限公司 2024-11-15 CN disclosed
CN-115703737-B Hydroxypyridones compound and application thereof as antibiotic sensitizer for overcoming bacterial biomembrane resistance 暨南大学 2024-09-24 CN disclosed
CN-117843579-A Benzo heterocycle coupled catechol derivative and preparation method and application thereof 暨南大学 2024-04-09 CN disclosed
CN-115260164-B Preparation method, structural composition and application of novel 4 (3H) -quinazolinone analogue in antitumor drugs 杭州星鳌生物科技有限公司 2024-03-26 CN disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed
US-4442294-A Process for the preparation of halo-2-mercaptobenzoxazoles HOECHST AKTIENGESELLSCHAFT (DE) 1984-04-10 US disclosed
EP-0104157-A1 Rubber compositions containing a vulcanization system alterative Monsanto Company (US) 1984-03-28 EP disclosed
EP-0079899-A1 TOPICAL COSMETIC PREPARATIONS CONTAINING HETERO-ARYL-MERCAPTO-ALKANOIC ACID DERIVATIVES AS ADDITIVES HAVING AN ANTI-SEBORRHEA ACITIVITY. HENKEL KGAA (DE) 1983-06-01 EP disclosed
WO-1982004391-A1 DERIVATIVES OF ARYL AND HETERO-ARYL-MERCAPTO-ALKANOIC ACIDS AS ADDITIVES HAVING AN ANTI-SEBORRHEA ACTIVITY FOR COSMETIC PRODUCTS MOELLER HINRICH 1982-12-23 WO disclosed
US-4234578-A ANTIBIOTICS CIBA-GEIGY CORPORATION (US) 1980-11-18 US disclosed
US-4069259-A Process for preparing organic disulfides ALLIED CHEMICAL CORPORATION (US) 1978-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250051319-A1 COMPOUNDS AND USE THEREOF AS HDAC6 INHIBITORS HDAC6, HDAC9, HDAC1 LMNA 2433/4885CYP1A2 3088/4885MAPT 119/4885
US-12613191-B2 Multiplexed Raman molecular imaging FABP1, SCNN1G, VIL1 LMNA 614/4885CYP1A2 2498/4885MAPT 2184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.