SCHEMBL4454889

SCHEMBL4454889

Fc1ccc2oc(S)nc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.45
GABRP O00591 3/20 0.40
GABRD O14764 3/20 0.40
GABRA1 P14867 3/20 0.40
GABRB1 P18505 3/20 0.40
GABRG2 P18507 3/20 0.40
GABRB3 P28472 3/20 0.40
GABRA5 P31644 3/20 0.40
GABRA3 P34903 3/20 0.40
GABRA2 P47869 3/20 0.40
GABRB2 P47870 3/20 0.40
GABRA4 P48169 3/20 0.40
GABRE P78334 3/20 0.40
GABRA6 Q16445 3/20 0.40
GABRG1 Q8N1C3 3/20 0.40
GABRG3 Q99928 3/20 0.40
GABRQ Q9UN88 3/20 0.40
DAGLA Q9Y4D2 1/20 0.39
F2RL3 Q96RI0 3/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29593303 1.00 MPO (0.45) MPOGABRPGABRDGABRA1GABRB1
SCHEMBL7488543 0.84 GABRP (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL29437032 0.76 XDH (0.42) KDM4EFBP1KMT2AMAPTLMNA
SCHEMBL135052 0.76 RAB9A (0.58) KDM4EKMT2AMAPTLMNA
SCHEMBL29593887 0.76 LMNA (0.61) KDM4EFBP1KMT2AMAPTLMNA
SCHEMBL9188510 0.76 RAB9A (0.58) KDM4EKMT2APIK3CBMAPTCYP1A2
SCHEMBL2548822 0.76 ESR1 (0.58) KMT2APIK3CBMAPT
SCHEMBL29593199 0.76 RAB9A (0.58) KDM4EKMT2AMAPTLMNA
SCHEMBL29361694 0.76 RAB9A (0.58) KDM4EKMT2APIK3CBMAPTCYP1A2
SCHEMBL1822085 0.76 XDH (0.42) KDM4EFBP1KMT2AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119923179-A Application of 5-fluorobenzoxazole-2-mercaptan, solar cell and preparation method thereof 中环新能(安徽)先进电池制造有限公司 2025-05-02 CN claimed
EP-3686203-B1 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF TANG YAJIE (CN) 2023-10-25 EP claimed
CN-108285456-B 4-sulfur substituted podophyllotoxin derivative and preparation method and application thereof 汤亚杰 2022-02-08 CN claimed
US-11242354-B2 4-sulfur substituted podophyllotoxin derivative and preparation method therefor and use thereof Tang, YaJie 2022-02-08 US claimed
EP-3686203-A1 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF Tang, Yajie (CN) 2020-07-29 EP claimed
CN-111454308-A Teniposide derivative and preparation method and application thereof 湖北工业大学 2020-07-28 CN claimed
US-20200216449-A1 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof Tang, YaJie (CN) 2020-07-09 US claimed
US-20200216462-A1 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof Tang, YaJie (CN) 2020-07-09 US claimed
US-12613191-B2 Multiplexed Raman molecular imaging UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2026-04-28 US disclosed
EP-4634175-A1 BENZIMIDAZOLE DERIVATIVES Immvention Therapeutix, Inc. (US) 2025-10-22 EP disclosed
CN-120058445-A Method for generating aryl phenol compound by hydroxylation of uranium photocatalytic aryl fluorine compound and application of method 华东师范大学 2025-05-30 CN disclosed
CN-119923179-A Application of 5-fluorobenzoxazole-2-mercaptan, solar cell and preparation method thereof 中环新能(安徽)先进电池制造有限公司 2025-05-02 CN disclosed
CN-119923179-A Application of 5-fluorobenzoxazole-2-mercaptan, solar cell and preparation method thereof 中环新能(安徽)先进电池制造有限公司 2025-05-02 CN disclosed
US-20240409533-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-12-12 US disclosed
WO-2009151744-A1 S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES GALLEON PHARMACEUTICALS, INC. (US) 2009-12-17 WO disclosed
EP-0883611-B1 AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 2002-07-31 EP disclosed
EP-0883611-A1 AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1998-12-16 EP disclosed
US-5736545-A ADMINISTERING TO TREAT BACTERIAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1998-04-07 US disclosed
WO-1997030981-A1 AZOLYL PIPERAZINYL PHENYL OXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1997-08-28 WO disclosed
EP-0572893-A1 Fluor-benzoxazolyloxyacetamides BAYER AG (DE) 1993-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12613191-B2 Multiplexed Raman molecular imaging FABP1, SCNN1G, VIL1 MPO 495/4885GABRP 1911/4885GABRD 2200/4885
US-20200216462-A1 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof WEE1, WEE2, DHFR MPO 1155/4885GABRP 2227/4885GABRD 2067/4885
US-20200216449-A1 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof TPMT, WEE1, DHFR MPO 1396/4885GABRP 1674/4885GABRD 1453/4885
US-20240409533-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS MPO 41/4885GABRP 2647/4885GABRD 1901/4885
US-11242354-B2 4-sulfur substituted podophyllotoxin derivative and preparation method therefor and use thereof WEE1, WEE2, DHFR MPO 1155/4885GABRP 2227/4885GABRD 2067/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.