SCHEMBL8600830

SCHEMBL8600830

CCOC(=O)C(C)Oc1cc(N=C=S)c(F)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPOX P50336 3/20 0.51
KMT2A Q03164 2/20 0.38
L3MBTL1 Q9Y468 3/20 0.37
LMNA P02545 1/20 0.37
EPHX2 P34913 2/20 0.36
KDM4E B2RXH2 5/20 0.35
ALDH1A1 P00352 4/20 0.35
HPGD P15428 3/20 0.35
MAPT P10636 3/20 0.35
HSD17B10 Q99714 3/20 0.35
TSHR P16473 2/20 0.35
MAPK1 P28482 2/20 0.35
ALOX15 P16050 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
TDP1 Q9NUW8 3/20 0.34
GAA P10253 2/20 0.34
HTT P42858 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8600214 0.90 PPOX (0.44) PPOXL3MBTL1LMNAKDM4EALDH1A1
SCHEMBL10578397 0.89 PPOX (0.52) PPOXKMT2AL3MBTL1LMNAEPHX2
SCHEMBL8603603 0.88 MAPT (0.39) PPOXKMT2AL3MBTL1LMNAKDM4E
SCHEMBL8601614 0.88 PPOX (0.43) PPOXL3MBTL1LMNAALDH1A1TSHR
SCHEMBL8599592 0.87 PPOX (0.38) PPOXLMNAKDM4EALDH1A1HPGD
SCHEMBL8599137 0.85 KDM4E (0.42) PPOXKMT2AKDM4EALDH1A1HPGD
SCHEMBL8602458 0.85 PPOX (0.44) PPOXKMT2AALDH1A1HPGDMAPT
SCHEMBL8598865 0.85 PPOX (0.37) PPOXHPGD
SCHEMBL8601864 0.82 CUL4A (0.44) PPOXKMT2ASMN1; SMN2
SCHEMBL8601518 0.81 PPOX (0.45) PPOXLMNAHPGDMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed
US-4812161-A HERBICIDES NIPPON SODA CO., LTD. (JP) 1989-03-14 US disclosed