SCHEMBL8600882

SCHEMBL8600882

Cc1ccccc1-c1c(C(=O)OC(C)C)c(C)nc2c1C(=O)OC2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNB4 O00305 1/20 0.43
CACNA1A O00555 1/20 0.43
CACNA1G O43497 1/20 0.43
CACNG3 O60359 1/20 0.43
CACNA1F O60840 1/20 0.43
CACNA1H O95180 1/20 0.43
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
CACNB3 P54284 1/20 0.43
CACNA2D1 P54289 1/20 0.43
CACNG7 P62955 1/20 0.43
CACNA1B Q00975 1/20 0.43
CACNA1D Q01668 1/20 0.43
CACNB1 Q02641 1/20 0.43
CACNG1 Q06432 1/20 0.43
CACNB2 Q08289 1/20 0.43
CACNA1S Q13698 1/20 0.43
CACNA1C Q13936 1/20 0.43
CACNA1E Q15878 1/20 0.43
CACNA2D4 Q7Z3S7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7967602 0.85 CACNB4 (0.39) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL7981539 0.79 SLC6A2 (0.44) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL11009475 0.76 CACNA1C (0.45) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL11006059 0.73 SMN1; SMN2 (0.39) CACNA1FCACNA1BCACNA1DCACNA1SCACNA1C
SCHEMBL8805653 0.70 CYP1A2 (0.46) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL10748490 0.70 TDP2 (0.38) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL7979243 0.70 CACNB4 (0.38) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL11010179 0.69 SMN1; SMN2 (0.66) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL7983845 0.68 LMNA (0.50) CACNB4CACNA1ACACNA1GCACNG3CACNA1F
SCHEMBL10748402 0.68 LDHA (0.45) ALDH1A1SMN1; SMN2HPGDLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5708177-A OXIDATION/REDUCTION OF OPPOSITE ENANTIOMERS BAYER AKTIENGESELLSCHAFT (DE) 1998-01-13 US disclosed
EP-0761651-A2 Process for preparing optically active ortho-substituted 4-aryl-dihydropyridines BAYER AG (DE) 1997-03-12 EP disclosed