Water

Water

SCHEMBL8601146

Cc1cccc(Nc2cccc(C)c2)c1.O

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.55
MEN1 known ✓ O00255 2/20 0.52
ADORA2A known ✓ P29274 1/20 0.50
EGFR known ✓ P00533 1/20 0.49
NPSR1 Q6W5P4 1/20 0.82
MAPT P10636 4/20 0.60
CYP1A2 P05177 2/20 0.60
HTT P42858 2/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C9 P11712 1/20 0.60
CYP2C19 P33261 1/20 0.60
NFKB1 P19838 1/20 0.57
HSD17B10 Q99714 1/20 0.54
ALDH1A1 P00352 2/20 0.52
KMT2A Q03164 2/20 0.52
AR P10275 1/20 0.52
GAA P10253 2/20 0.52
HAVCR2 Q8TDQ0 1/20 0.50
CCR4 P51679 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1009206 0.97 NPSR1 (0.86) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL29650380 0.97 NPSR1 (0.86) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL9158496 0.95 NPSR1 (0.82) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL30145137 0.92 NPSR1 (0.86) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL1690867 0.92 NPSR1 (0.78) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL10523964 0.92 NPSR1 (0.86) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL1922070 0.92 NPSR1 (0.86) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL30416120 0.90 NPSR1 (1.00) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL234363 0.90 NPSR1 (1.00) NPSR1MAPTCYP1A2HTTCYP3A4
SCHEMBL30661288 0.90 NPSR1 (0.75) NPSR1MAPTCYP1A2HTTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0494535-B1 Process for producing epsilon-caprolactam and activating solid catalysts therefor SUMITOMO CHEMICAL CO (JP) 1998-02-18 EP disclosed
US-5403801-A Contacting zeolite with either aqueous solution of ammonium salts and base, or ammonia water SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-04-04 US disclosed
US-5212302-A Catalytic reaction of cyclohexanone oxime SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1993-05-18 US disclosed
EP-0494535-A1 Process for producing epsilon-caprolactam and activating solid catalysts therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-07-15 EP disclosed