Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599642 | 0.84 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601399 | 0.83 | MEN1 (0.39) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601274 | 0.83 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601071 | 0.82 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL8600463 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8604472 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8601171 | 0.77 | NR1D1 (0.40) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL8604717 | 0.76 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL8603224 | 0.75 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8600001 | 0.75 | CNR1 (0.40) | PDE4APDE4BPDE4CPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |