SCHEMBL8601376

SCHEMBL8601376

Oc1cc(N=C=S)c(F)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
HSD17B1 P14061 1/20 0.30
HSD17B2 P37059 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11552834 0.82 KDM1A (0.36) HPGDHSD17B10
SCHEMBL8599218 0.78
SCHEMBL17651437 0.78 CD44 (0.33)
SCHEMBL10440534 0.78 ALDH1A1 (0.34) HPGDHSD17B10HSD17B1HSD17B2
SCHEMBL9419231 0.77
SCHEMBL17651060 0.76 ABCB11 (0.31) HPGDHSD17B10
SCHEMBL9492204 0.76 KEAP1 (0.38) HPGDTSHR
SCHEMBL6722274 0.75 TRPV4 (0.35) HSD17B1HSD17B2
SCHEMBL9419230 0.75 POLB (0.33) HPGDTSHR
SCHEMBL8603166 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626370-B1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL CO (JP) 1998-02-11 EP disclosed
CN-1027030-C Fused heterocyclic compound-containing herbicides, process for production thereof and use thereof NISSAN CHEMICAL IND LTD (JP) 1994-12-21 CN disclosed
EP-0626370-A1 Process for producing aromatic isothiocyanate derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1994-11-30 EP disclosed
US-5039331-A Condensed heterocyclic derivatives and herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-08-13 US disclosed
CN-1032013-A Condensed heterocyclic derivates and production method thereof and weedicide NISSAN CHEMICAL IND LTD (JP) 1989-03-29 CN disclosed
EP-0304920-A2 Condensed heterocyclic derivatives, process for their production and herbicides NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1989-03-01 EP disclosed