8-Aminoquinoline

8-Aminoquinoline

SCHEMBL860459

Nc1cccc2cccnc12.Nc1cccc2ncccc12.Nc1cccc2nccnc12

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.53
NCF1 P14598 1/20 0.51
MAPT P10636 5/20 0.45
KMT2A Q03164 5/20 0.45
MEN1 O00255 4/20 0.45
HSP90AA1 P07900 3/20 0.45
HSP90AB1 P08238 2/20 0.45
HTT P42858 2/20 0.45
HIF1A Q16665 2/20 0.45
BLM P54132 1/20 0.45
IDO1 P14902 1/20 0.42
PSMB5 P28074 1/20 0.42
CYP3A4 P08684 3/20 0.42
ALDH1A1 P00352 5/20 0.41
NR4A2 P43354 2/20 0.41
APAF1 O14727 1/20 0.41
TDP2 O95551 1/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Aminoquinoline SCHEMBL7870947 0.84 NCF1 (0.57) LMNANCF1MAPTKMT2AMEN1
SCHEMBL29961464 0.83 NCF1 (0.72) LMNANCF1MAPTKMT2AMEN1
SCHEMBL115674 0.83 NCF1 (0.72) LMNANCF1MAPTKMT2AMEN1
8-Aminoquinoline SCHEMBL28078884 0.82 ALDH1A1 (0.63) LMNANCF1MAPTKMT2AMEN1
Hydrochloric Acid SCHEMBL29862816 0.81 NCF1 (0.69) LMNANCF1MAPTKMT2AMEN1
Ammonia Solution, Strong SCHEMBL14322575 0.81 NCF1 (0.69) LMNANCF1MAPTKMT2AMEN1
Hydrochloric Acid SCHEMBL6119015 0.81 NCF1 (0.69) LMNANCF1MAPTKMT2AMEN1
8-Aminoquinoline SCHEMBL159694 0.81 LMNA (0.61) LMNAMAPTKMT2AMEN1HSP90AA1
8-Aminoquinoline SCHEMBL29735354 0.81 LMNA (0.61) LMNAMAPTKMT2AMEN1HSP90AA1
SCHEMBL825817 0.81 MAPT (0.54) LMNANCF1MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2588144-A2 DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY Ventana Medical Systems, Inc. (US) 2013-05-08 EP disclosed
WO-2012003478-A2 DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY VENTANA MEDICAL SYSTEMS, INC. (US) 2012-01-05 WO disclosed