Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604772 | 0.84 | PTGS2 (0.44) | PTGS1PTGS2CA2CA9 | |
| SCHEMBL6316751 | 0.78 | F10 (0.38) | F10PTGS1PTGS2 | |
| SCHEMBL6314463 | 0.76 | PTGS2 (0.36) | F10SCN9APTGS1PTGS2MMP2 | |
| SCHEMBL6314893 | 0.75 | ALOX5 (0.36) | F10SCN9APTGS1PTGS2MMP2 | |
| Methane SCHEMBL6315337 | 0.74 | PTGS2 (0.35) | F10PTGS1PTGS2MMP2MMP9 | |
| SCHEMBL8605986 | 0.72 | RXRA (0.43) | F10NAMPTCA2CA9 | |
| SCHEMBL8604310 | 0.72 | RXRA (0.43) | F10NAMPTCA2CA9 | |
| SCHEMBL6309624 | 0.72 | PTGS2 (0.41) | F10SCN9APTGS1PTGS2 | |
| SCHEMBL6308474 | 0.70 | PTGS2 (0.37) | F10PTGS1PTGS2CA9 | |
| SCHEMBL6309332 | 0.69 | KDM4E (0.40) | F10PTGS2MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |