Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840299 | 0.82 | BACE1 (0.40) | BACE1RENALDH1A1NPC1RAB9A | |
| SCHEMBL7360719 | 0.82 | BACE1 (0.36) | BACE1RENNPC1RAB9AMAPT | |
| SCHEMBL5689224 | 0.81 | PSEN1 (0.40) | BACE1REN | |
| SCHEMBL7399391 | 0.81 | PSEN1 (0.40) | BACE1REN | |
| SCHEMBL8899924 | 0.79 | BACE1 (0.36) | BACE1RENNPC1RAB9AMAPT | |
| SCHEMBL7353583 | 0.78 | BACE1 (0.37) | BACE1REN | |
| SCHEMBL8897548 | 0.77 | BACE1 (0.33) | BACE1RENALDH1A1 | |
| SCHEMBL7360716 | 0.77 | BACE1 (0.36) | BACE1RENCCR1NPC1RAB9A | |
| SCHEMBL7476233 | 0.76 | SPPL2A (0.38) | BACE1CCR1 | |
| SCHEMBL6430008 | 0.75 | LAP3 (0.49) | RENNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750648-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1998-05-12 | — | — | US | disclosed |