Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360719 | 0.87 | BACE1 (0.36) | BACE1RENCTSDSPPL2A | |
| SCHEMBL8899924 | 0.84 | BACE1 (0.36) | BACE1RENCTSD | |
| SCHEMBL7353583 | 0.83 | BACE1 (0.37) | BACE1RENCTSD | |
| SCHEMBL7424741 | 0.82 | HTT (0.46) | RENHTTADAM17 | |
| SCHEMBL7424747 | 0.82 | HTT (0.46) | RENHTTADAM17 | |
| SCHEMBL7476233 | 0.81 | SPPL2A (0.38) | BACE1CTSDSPPL2A | |
| SCHEMBL7353051 | 0.80 | ADAM17 (0.44) | HTTCTSDADAM17 | |
| SCHEMBL7353045 | 0.80 | ADAM17 (0.44) | HTTCTSDADAM17 | |
| SCHEMBL8606263 | 0.77 | BACE1 (0.35) | BACE1RENALDH1A1 | |
| SCHEMBL7352170 | 0.77 | GAA (0.39) | BACE1RENALDH1A1CYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614522-A | SULFONAMIDE AND UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS | G.D. SEARLE & CO. (US) | 1997-03-25 | — | — | US | disclosed |