Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899924 | 0.90 | BACE1 (0.36) | BACE1CTSDRENNPC1RAB9A | |
| SCHEMBL7353583 | 0.88 | BACE1 (0.37) | BACE1CTSDBACE2REN | |
| SCHEMBL8897548 | 0.87 | BACE1 (0.33) | BACE1CTSDRENSPPL2A | |
| SCHEMBL7476233 | 0.86 | SPPL2A (0.38) | BACE1CTSDSPPL2A | |
| SCHEMBL8606263 | 0.82 | BACE1 (0.35) | BACE1RENNPC1RAB9AMAPT | |
| SCHEMBL7360716 | 0.82 | BACE1 (0.36) | BACE1CTSDRENNPC1RAB9A | |
| SCHEMBL8840299 | 0.82 | BACE1 (0.40) | BACE1RENNPC1RAB9AMAPT | |
| SCHEMBL7358895 | 0.78 | REN (0.38) | CTSDREN | |
| SCHEMBL8897311 | 0.76 | REN (0.38) | RENNPC1RAB9AMAPT | |
| SCHEMBL8897322 | 0.76 | REN (0.38) | RENNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614522-A | SULFONAMIDE AND UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS | G.D. SEARLE & CO. (US) | 1997-03-25 | — | — | US | disclosed |
| EP-0558673-A1 | RETROVIRAL PROTEASE INHIBITORS. | MONSANTO CO (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992008699-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |