Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360716 | 0.90 | BACE1 (0.36) | BACE1NPC1RAB9AMAPTREN | |
| SCHEMBL7353577 | 0.85 | REN (0.34) | BACE1REN | |
| SCHEMBL8606263 | 0.82 | BACE1 (0.35) | BACE1NPC1RAB9AMAPTREN | |
| SCHEMBL7360719 | 0.82 | BACE1 (0.36) | BACE1NPC1RAB9AMAPTREN | |
| SCHEMBL7547746 | 0.81 | LAP3 (0.49) | NPC1RAB9AMAPTRENLMNA | |
| SCHEMBL6430008 | 0.81 | LAP3 (0.49) | NPC1RAB9AMAPTRENLMNA | |
| SCHEMBL8899924 | 0.81 | BACE1 (0.36) | BACE1NPC1RAB9AMAPTREN | |
| SCHEMBL9742824 | 0.80 | NPC1 (0.51) | BACE1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6448962 | 0.80 | NPC1 (0.51) | BACE1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7360300 | 0.80 | BACE1 (0.40) | BACE1RENBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622949-A | AIDS THERAPY | G. D. SEARLE & CO. (US) | 1997-04-22 | — | — | US | disclosed |
| US-5620977-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1997-04-15 | — | — | US | disclosed |