Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | FABP2 | P12104 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 3/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12603986 | 0.75 | ALDH1A1 (0.42) | KDM4EMEN1CYP2C19KMT2AALDH1A1 | |
| SCHEMBL8605894 | 0.71 | L3MBTL1 (0.39) | CYP3A4KDM4ECYP1A2MEN1CYP2C19 | |
| SCHEMBL7552061 | 0.69 | ALDH1A1 (0.44) | PPARACYP3A4KDM4ECYP1A2MEN1 | |
| SCHEMBL22109267 | 0.69 | KDM4E (0.38) | KDM4EALDH1A1PDE10AMAPK1 | |
| SCHEMBL8606554 | 0.68 | KDM4E (0.32) | CYP3A4KDM4EMAPTALDH1A1POLB | |
| SCHEMBL8607084 | 0.63 | SCN5A (0.42) | KDM4EMAPTALDH1A1POLBSCN5A | |
| SCHEMBL2492473 | 0.63 | ALDH1A1 (0.46) | KDM4ECYP1A2MEN1MAPTKMT2A | |
| SCHEMBL4820655 | 0.62 | PPARA (0.55) | PPARACYP3A4CYP1A2MEN1MAPT | |
| SCHEMBL18676744 | 0.60 | MAOA (0.42) | PPARACYP3A4KDM4ECYP1A2MEN1 | |
| SCHEMBL9933093 | 0.60 | PDE10A (0.45) | KDM4ECYP2C19ALDH1A1PDE10AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753665-A | TRIAZOLOPYRIMIDINES, NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | claimed |
| US-5753665-A | TRIAZOLOPYRIMIDINES, NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |