Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604308 | 0.89 | RXRA (0.47) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL8605984 | 0.89 | RXRA (0.47) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL6860698 | 0.89 | PTGS2 (0.59) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL8604016 | 0.86 | CA2 (0.44) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL6308685 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL8607286 | 0.84 | PTGS1 (0.40) | PTGS2PTGS1CA9NR4A2 | |
| SCHEMBL7508637 | 0.82 | PTGS2 (0.67) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL7503465 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1MAOAMAOBCA2 | |
| SCHEMBL9097538 | 0.80 | NR4A2 (0.56) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8604398 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828718-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038418-A1 | HETEROCYCLO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 AND 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-05 | — | — | WO | disclosed |