Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30594489 | 0.81 | MTNR1A (0.58) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL745297 | 0.81 | MTNR1A (0.58) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL30567224 | 0.78 | MAPT (0.62) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL2855386 | 0.78 | MAPT (0.62) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL9464673 | 0.76 | CDC25B (0.55) | LMNAMAPK1HSD17B10ALDH1A1HPGD | |
| SCHEMBL8884808 | 0.76 | MTNR1A (0.74) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL31387888 | 0.75 | KDM4E (0.59) | HTTLMNAMTNR1AMAPK1HSD17B10 | |
| SCHEMBL8662697 | 0.75 | CASP6 (0.59) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL2856689 | 0.74 | LMNA (0.55) | HTTLMNATSHRHSD17B1HSD17B2 | |
| SCHEMBL6247493 | 0.74 | MTNR1A (0.72) | MTNR1AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662471-B1 | Naphthalene derivatives with affinity to the receptors of melatonine, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-03-11 | — | — | EP | disclosed |
| EP-0662471-A2 | Naphthalene derivatives with affinity to the receptors of melatonine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-07-12 | — | — | EP | disclosed |