Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADH1A | P07327 | 3/20 | 0.40 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | ADH1C | P00326 | 2/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6255211 | 0.98 | THRA (0.42) | THRATHRBADH1ANAAAADH1C | |
| SCHEMBL9071877 | 0.95 | L3MBTL1 (0.41) | THRATHRBADH1ANAAAADH1C | |
| Hydrochloric Acid SCHEMBL27363306 | 0.89 | ADH1C (0.44) | ADH1ANAAAADH1CADH4L3MBTL1 | |
| SCHEMBL27971919 | 0.87 | ADH1A (0.47) | ADH1AADH1CL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27529969 | 0.86 | ADH1A (0.46) | ADH1AADH1CL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27321586 | 0.84 | ADH1A (0.44) | ADH1AADH1CL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27341644 | 0.84 | L3MBTL1 (0.43) | ADH1AADH1CADH4L3MBTL1 | |
| SCHEMBL5146008 | 0.83 | NAAA (0.40) | ADH1ANAAAADH1CADH4EPHX1 | |
| SCHEMBL7715306 | 0.83 | NAAA (0.40) | ADH1ANAAAADH1CADH4EPHX1 | |
| SCHEMBL22023395 | 0.83 | NAAA (0.46) | THRATHRBADH1ANAAAADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160318856-A1 | Substituted Urea eIF2alpha Kinase Activators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-03 | — | — | US | disclosed |
| WO-2015038778-A1 | SUBSTITUTED UREA EIF2α KINASE ACTIVATORS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2015-03-19 | — | — | WO | disclosed |
| US-5767113-A | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1998-06-16 | — | — | US | disclosed |
| WO-1996035426-A1 | COMPOUNDS USEFUL FOR CONCURRENTLY ACTIVATING GLUCOCORTICOID-INDUCED RESPONSE AND REDUCING MULTIDRUG RESISTANCE | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318856-A1 | Substituted Urea eIF2alpha Kinase Activators | EIF2AK1, EIF2A, EIF4A2 | THRA 2559/4885THRB 2692/4885ADH1A 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.