Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861661 | 0.81 | SIGMAR1 (0.42) | SIGMAR1DRD2DRD4DRD3ESR1 | |
| SCHEMBL2598136 | 0.74 | BRD4 (0.41) | SIGMAR1DRD2DRD4DRD3MEN1 | |
| SCHEMBL861689 | 0.74 | DRD2 (0.38) | SIGMAR1DRD2DRD4DRD3FUCA1 | |
| Hydrochloric Acid SCHEMBL2268301 | 0.72 | SIGMAR1 (0.43) | SIGMAR1DRD4FUCA1MEN1KMT2A | |
| SCHEMBL24326131 | 0.59 | ALDH1A1 (0.50) | SIGMAR1ESR1ESR2FUCA1S1PR1 | |
| SCHEMBL477142 | 0.58 | FUCA1 (0.55) | SIGMAR1DRD2DRD3FUCA1S1PR1 | |
| SCHEMBL4279682 | 0.58 | FUCA1 (0.55) | SIGMAR1FUCA1S1PR1S1PR5MEN1 | |
| SCHEMBL3522693 | 0.58 | FUCA1 (0.55) | SIGMAR1FUCA1S1PR1S1PR5MEN1 | |
| SCHEMBL3522692 | 0.58 | FUCA1 (0.55) | SIGMAR1FUCA1S1PR1S1PR5MEN1 | |
| SCHEMBL3324661 | 0.58 | FUCA1 (0.55) | SIGMAR1FUCA1S1PR1S1PR5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |