Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860866 | 0.74 | SIGMAR1 (0.37) | DRD4SIGMAR1MEN1KMT2ADRD2 | |
| SCHEMBL861661 | 0.72 | SIGMAR1 (0.42) | DRD4ALDH1A1SIGMAR1DRD2DRD3 | |
| SCHEMBL861689 | 0.70 | DRD2 (0.38) | DRD4SIGMAR1DRD2DRD3BCHE | |
| Hydrochloric Acid SCHEMBL2268301 | 0.66 | SIGMAR1 (0.43) | DRD4ALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL3051745 | 0.62 | REV1 (0.64) | DRD4GAAMAPTSIGMAR1KMT2A | |
| SCHEMBL23507478 | 0.62 | KMT2A (0.64) | DRD4SIGMAR1MEN1KMT2AHTR1A | |
| SCHEMBL2316528 | 0.61 | KDM4E (0.77) | ALDH1A1GAAMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL12582003 | 0.60 | ALDH1A1 (0.49) | ALDH1A1GAAMAPTPAX8SMN1; SMN2 | |
| SCHEMBL10970487 | 0.59 | MCHR1 (0.58) | DRD4ALDH1A1GAASMN1; SMN2SIGMAR1 | |
| SCHEMBL6572711 | 0.59 | SIGMAR1 (0.64) | DRD4SIGMAR1MEN1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |