Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 8/20 | 0.38 |
| ▸ | BACE1 | P56817 | 7/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861661 | 0.83 | SIGMAR1 (0.42) | DRD2DRD3DRD4FUCA1SIGMAR1 | |
| SCHEMBL860866 | 0.74 | SIGMAR1 (0.37) | DRD2DRD3DRD4FUCA1SIGMAR1 | |
| SCHEMBL2598136 | 0.70 | BRD4 (0.41) | DRD2DRD3BCHEDRD4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2268301 | 0.70 | SIGMAR1 (0.43) | ACHEDRD4FUCA1SIGMAR1 | |
| SCHEMBL4404973 | 0.64 | DRD2 (0.55) | DRD2DRD3ACHEBACE1BCHE | |
| SCHEMBL4224135 | 0.62 | SIGMAR1 (0.55) | DRD2DRD3ACHEBACE1BCHE | |
| SCHEMBL8725812 | 0.62 | SIGMAR1 (0.75) | ACHEBACE1BCHESIGMAR1 | |
| SCHEMBL16225922 | 0.62 | ALDH1A1 (0.74) | SIGMAR1 | |
| SCHEMBL16226988 | 0.60 | ACHE (0.69) | ACHEBACE1BCHESIGMAR1 | |
| SCHEMBL16227202 | 0.60 | SIGMAR1 (0.60) | ACHEBACE1BCHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |