Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.52 |
| ▸ | Q9HBH1 | 7/20 | 0.49 | |
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP3 | P08254 | 5/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
| ▸ | RRM2 | P31350 | 1/20 | 0.34 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20628537 | 0.74 | MME (0.69) | MMEMMP1MMP3MMP9MMP2 | |
| SCHEMBL8613311 | 0.73 | FOLH1 (0.50) | PDFMMP1MMP3MMP9MMP2 | |
| SCHEMBL14282150 | 0.71 | PDF (0.70) | PDFMMP1MMP3MMP9MMP2 | |
| SCHEMBL14779147 | 0.70 | PDF (0.51) | ||
| SCHEMBL8269110 | 0.69 | MME (0.61) | MMEMMP1MMP3MMP9MMP2 | |
| SCHEMBL10424915 | 0.68 | MME (0.51) | MMEMMP1MMP3MMP9MMP2 | |
| SCHEMBL14011129 | 0.68 | MME (0.51) | MMEMMP1MMP3MMP9MMP2 | |
| SCHEMBL8773896 | 0.67 | MME (0.60) | MMEPDFMMP1MMP3MMP9 | |
| SCHEMBL14566818 | 0.67 | MMP1 (0.71) | PDFMMP1MMP3MMP9MMP2 | |
| SCHEMBL8189153 | 0.67 | MMP1 (0.71) | PDFMMP1MMP3MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |