Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.50 |
| ▸ | Q9HBH1 | 7/20 | 0.41 | |
| ▸ | LAP3 | P28838 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612045 | 0.83 | FOLH1 (0.52) | FOLH1LAP3MMP9MMP8 | |
| SCHEMBL8612042 | 0.83 | FOLH1 (0.52) | FOLH1LAP3MMP9MMP8 | |
| SCHEMBL8610878 | 0.81 | FOLH1 (0.61) | FOLH1LAP3 | |
| SCHEMBL8610880 | 0.81 | FOLH1 (0.61) | FOLH1LAP3 | |
| SCHEMBL8614433 | 0.80 | CTSK (0.48) | — | |
| SCHEMBL8613294 | 0.77 | FOLH1 (0.49) | FOLH1LAP3 | |
| SCHEMBL8613767 | 0.77 | FOLH1 (0.49) | FOLH1LAP3 | |
| SCHEMBL8609901 | 0.73 | MME (0.52) | PDFMMP1MMP3MMP9ADAM17 | |
| SCHEMBL7308675 | 0.72 | FOLH1 (0.53) | FOLH1LAP3 | |
| SCHEMBL3222189 | 0.72 | POLB (0.37) | FOLH1LAP3MMP1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |