Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.51 |
| ▸ | LAP3 | P28838 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614503 | 0.84 | FOLH1 (0.50) | FOLH1LAP3ALDH1A1CTSSCTSK | |
| SCHEMBL8613767 | 0.83 | FOLH1 (0.49) | FOLH1LAP3ALDH1A1CTSSCTSK | |
| SCHEMBL8613294 | 0.83 | FOLH1 (0.49) | FOLH1LAP3ALDH1A1CTSSCTSK | |
| SCHEMBL8898663 | 0.80 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1CTSSCTSK | |
| SCHEMBL8898668 | 0.79 | CTSL (0.41) | HSP90AA1HSP90AB1CTSSCTSK | |
| SCHEMBL8608760 | 0.78 | FOLH1 (0.44) | FOLH1LAP3ALDH1A1 | |
| SCHEMBL8610073 | 0.76 | L3MBTL1 (0.45) | FOLH1ALDH1A1L3MBTL1 | |
| SCHEMBL20707063 | 0.76 | ENPEP (0.44) | ALDH1A1ENPEPCTSSCTSKL3MBTL1 | |
| SCHEMBL14865078 | 0.76 | ENPEP (0.44) | ALDH1A1ENPEPCTSSCTSKL3MBTL1 | |
| SCHEMBL12654464 | 0.76 | ENPEP (0.44) | ALDH1A1ENPEPCTSSCTSKL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |