Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898176 | 0.83 | MEN1 (0.49) | MEN1KMT2ATSHREPHX1ALDH1A1 | |
| SCHEMBL8614503 | 0.83 | FOLH1 (0.50) | MEN1KMT2AFOLH1ALDH1A1 | |
| SCHEMBL8898177 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL8610979 | 0.81 | MEN1 (0.47) | MEN1KMT2ATSHRFOLH1EPHX1 | |
| SCHEMBL15104808 | 0.77 | L3MBTL1 (0.55) | L3MBTL1MEN1KMT2ATSHREPHX1 | |
| SCHEMBL3728556 | 0.77 | L3MBTL1 (0.55) | L3MBTL1MEN1KMT2ATSHREPHX1 | |
| SCHEMBL8608760 | 0.77 | FOLH1 (0.44) | FOLH1ALDH1A1 | |
| SCHEMBL8610024 | 0.76 | FOLH1 (0.51) | L3MBTL1FOLH1ALDH1A1 | |
| SCHEMBL12572626 | 0.76 | CTSS (0.57) | L3MBTL1MEN1KMT2AEPHX1ALDH1A1 | |
| SCHEMBL8613767 | 0.74 | FOLH1 (0.49) | L3MBTL1MEN1KMT2AFOLH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |