SCHEMBL8614503

SCHEMBL8614503

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nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 6/20 0.50
ALDH1A1 P00352 2/20 0.45
CTSS P25774 2/20 0.41
CTSK P43235 1/20 0.41
LAP3 P28838 2/20 0.38
CTSL P07711 1/20 0.37
CTSB P07858 1/20 0.37
MEN1 O00255 2/20 0.36
LMNA P02545 2/20 0.36
KMT2A Q03164 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8610024 0.84 FOLH1 (0.51) FOLH1ALDH1A1CTSSCTSKLAP3
SCHEMBL8610073 0.83 L3MBTL1 (0.45) FOLH1ALDH1A1MEN1KMT2A
SCHEMBL8613767 0.82 FOLH1 (0.49) FOLH1ALDH1A1CTSSCTSKLAP3
SCHEMBL8613294 0.82 FOLH1 (0.49) FOLH1ALDH1A1CTSSCTSKLAP3
SCHEMBL8895941 0.80 CTSB (0.56) CTSSCTSKCTSLCTSBMEN1
SCHEMBL8608760 0.80 FOLH1 (0.44) FOLH1ALDH1A1LAP3
SCHEMBL8895944 0.79 CTSL (0.45) CTSSCTSKCTSLCTSBMEN1
SCHEMBL8612045 0.71 FOLH1 (0.52) FOLH1ALDH1A1CTSSCTSKLAP3
SCHEMBL8612042 0.71 FOLH1 (0.52) FOLH1ALDH1A1CTSSCTSKLAP3
SCHEMBL9830222 0.71 ALDH1A1 (0.58) ALDH1A1CTSSCTSKMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0457195-B1 Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same FUJISAWA PHARMACEUTICAL CO (JP) 1998-04-15 EP disclosed
US-5656604-A HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-08-12 US disclosed
US-5430022-A Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-07-04 US disclosed
US-5284828-A Hypotensive agents FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 1994-02-08 US disclosed