Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707208 | 0.87 | NPC1 (0.45) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL12231965 | 0.87 | GAA (0.44) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL21422893 | 0.87 | GAA (0.44) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL20047441 | 0.83 | GAA (0.41) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL2756559 | 0.82 | SMN1; SMN2 (0.61) | GAASMN1; SMN2ALDH1A1TP53NPC1 | |
| SCHEMBL2615995 | 0.82 | GAA (0.52) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL12205823 | 0.80 | NPC1 (0.38) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL13729643 | 0.78 | GLP1R (0.38) | GAASMN1; SMN2ALDH1A1TP53CYP3A4 | |
| SCHEMBL26438869 | 0.78 | ACACB (0.41) | GAASMN1; SMN2ALDH1A1TP53NPC1 | |
| SCHEMBL24466885 | 0.77 | HSD17B10 (0.46) | GAASMN1; SMN2ALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9301953-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2016-04-05 | — | — | US | disclosed |
| US-8921373-B2 | Compounds having TRPV1 antagonistic activity and uses thereof | SHIONOGI & CO., LTD. (JP) | 2014-12-30 | — | — | US | disclosed |
| US-20140249185-A1 | Therapeutic Agents Useful for Treating Pain | PURDUE PHARMA L.P. (US) | 2014-09-04 | — | — | US | disclosed |
| US-8785445-B2 | 7-phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8637548-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130123239-A1 | COMPOUNDS HAVING TRPV1 ANTAGONISTIC ACTIVITY AND USES THEREOF | PURDUE PHARMA L.P. | 2013-05-16 | — | — | US | disclosed |
| US-8178560-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20120101103-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-8129388-B2 | Therapeutic agents useful for treating pain | Purde Pharma L.P. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110288100-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2011-11-24 | — | — | US | disclosed |
| US-7994177-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2011-08-09 | — | — | US | disclosed |
| US-7964606-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2011-06-21 | — | — | US | disclosed |
| US-20110071192-A1 | Therapeutic Agents Useful for Treating Pain | PURDUE PHARMA L.P. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110009418-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2011-01-13 | — | — | US | disclosed |
| US-20100331369-A1 | Therapeutic Agents Useful for Treating Pain | PURDUE PHARMA L.P. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100317670-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2010-12-16 | — | — | US | disclosed |
| US-7799807-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7776861-B2 | Cycloheteroalkenyl compounds used as analgesics and for treating incontinence, inflammatory bowel disease, Parkinson's disease, amyotrophic lateral sclerosis, dementia, epilepsy, retinopathy, pruritus, psychoses, Huntington's disease, headaches, vomiting, dyskinesia or as anxiolytics and antidepressants | PURDUE PHARMA L.P. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7772254-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20070027159-A1 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331369-A1 | Therapeutic Agents Useful for Treating Pain | GRIN1, GRIK1, GRIN2B | GAA 1032/4885SMN1; SMN2 25/4885ALDH1A1 1552/4885 |
| US-20110009418-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | OPRL1, OPRK1, TRPV1 | GAA 4216/4885SMN1; SMN2 368/4885ALDH1A1 407/4885 |
| US-20070027159-A1 | Therapeutic agents useful for treating pain | ARRB1, FPR1, OPRL1 | GAA 4548/4885SMN1; SMN2 899/4885ALDH1A1 875/4885 |
| US-20110071192-A1 | Therapeutic Agents Useful for Treating Pain | GRIN1, GRIK1, GRIN2B | GAA 1032/4885SMN1; SMN2 25/4885ALDH1A1 1552/4885 |
| US-20130123239-A1 | COMPOUNDS HAVING TRPV1 ANTAGONISTIC ACTIVITY AND USES THEREOF | TRPV1, TRPA1, TRPV2 | GAA 2938/4885SMN1; SMN2 2293/4885ALDH1A1 1526/4885 |
| US-20110288100-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | OPRL1, OPRK1, MTNR1A | GAA 4653/4885SMN1; SMN2 279/4885ALDH1A1 652/4885 |
| US-20140249185-A1 | Therapeutic Agents Useful for Treating Pain | GRIN1, GRIK1, GRIN2B | GAA 1032/4885SMN1; SMN2 25/4885ALDH1A1 1552/4885 |
| US-20100317670-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | OPRL1, OPRK1, MTNR1A | GAA 4653/4885SMN1; SMN2 279/4885ALDH1A1 652/4885 |
| US-20120101103-A1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | PTGDR2, PTGDR, HRH2 | GAA 4302/4885SMN1; SMN2 4615/4885ALDH1A1 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.