Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25060877 | 0.87 | P2RX1 (0.43) | HSD17B10POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8611027 | 0.81 | TACR1 (0.41) | ALDH1A1PTPN5CNR1CNR2TACR1 | |
| SCHEMBL6251039 | 0.81 | TSHR (0.42) | ALDH1A1P2RX1P2RX4P2RX7MAPK1 | |
| SCHEMBL26083661 | 0.80 | P2RX1 (0.38) | HSD17B10POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8615377 | 0.78 | P2RX1 (0.39) | HSD17B10POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8613773 | 0.78 | P2RX1 (0.39) | KDM4EP2RX1P2RX4P2RX7LMNA | |
| SCHEMBL2322069 | 0.76 | ALDH1A1 (0.46) | HSD17B10POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL30422061 | 0.76 | ALDH1A1 (0.46) | HSD17B10POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8614289 | 0.73 | LMNA (0.40) | HSD17B10KDM4EALDH1A1PTPN5TP53 | |
| SCHEMBL25060875 | 0.71 | NPC1 (0.41) | HSD17B10POLBKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789623-A | Process for the preparation of hydroxybiarylphosphines and novel compounds of this group of substances | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-04 | — | — | US | disclosed |
| EP-0748811-A1 | Process for the preparation of hydroxybiarylphosphanes and novel compounds from this materials group | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |