SCHEMBL8611561

SCHEMBL8611561

CC1(COc2ccc(S(=O)(=O)c3ccc(Cl)cc3Cl)cc2)CO1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.44
TRPV4 Q9HBA0 5/20 0.43
TRPM8 Q7Z2W7 2/20 0.43
NAMPT P43490 3/20 0.40
KCNH2 Q12809 1/20 0.38
MAPT P10636 3/20 0.37
HTT P42858 2/20 0.37
TP53 P04637 2/20 0.37
MEN1 O00255 2/20 0.37
ALDH1A1 P00352 2/20 0.37
KMT2A Q03164 2/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
HSD17B10 Q99714 1/20 0.37
PPARG P37231 1/20 0.37
CNR2 P34972 1/20 0.36
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
ADAMTS4 O75173 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7720231 0.76 PKM (0.51) MAPTHTTALDH1A1KMT2ALMNA
SCHEMBL6296946 0.76 ALDH1A1 (0.66) HSD11B1TRPV4TRPM8NAMPTMAPT
SCHEMBL11738646 0.73 NPSR1 (0.40) KCNH2MAPTLMNAMAPK1NPSR1
SCHEMBL5481274 0.72 HSD11B1 (0.62) HSD11B1NAMPTMEN1ALDH1A1KMT2A
SCHEMBL6301749 0.72 MAOB (0.48) MAPTHTTALDH1A1SMN1; SMN2MMP13
SCHEMBL31349 0.72 CA12 (0.52) SMN1; SMN2ADAMTS4MMP13MMP2MMP1
SCHEMBL5707066 0.71 CA12 (0.43) MAPTLMNASMN1; SMN2MMP13MMP1
SCHEMBL8611881 0.71 PKM (0.49) MAPTHTTALDH1A1GAAPOLB
SCHEMBL14431510 0.70 HSD11B1 (0.59) HSD11B1NAMPTALDH1A1PPARGCNR2
SCHEMBL11279180 0.69 LMNA (0.46) KCNH2HTTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664224-B1 Heat-sensitive recording paper NEW OJI PAPER CO LTD (JP) 1998-04-22 EP disclosed
US-5543382-A GLASSINE PAPER, LEUCO DYE AND DEVELOPER NEW OJI PAPER CO., LTD. (JP) 1996-08-06 US disclosed
EP-0664224-A2 Heat-sensitive recording paper NEW OJI PAPER CO., LTD. (JP) 1995-07-26 EP disclosed