Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613817 | 0.85 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL8611842 | 0.80 | ALDH1A1 (0.42) | TDP2HTTCYP3A4 | |
| SCHEMBL8613975 | 0.78 | KDM4E (0.30) | — | |
| SCHEMBL8611699 | 0.77 | ADRA2A (0.34) | ADRA2AADRA2BADRA2C | |
| SCHEMBL8611882 | 0.76 | ALDH1A1 (0.39) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL5827498 | 0.72 | PNMT (0.47) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1394805 | 0.71 | TDP2 (0.47) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL1393796 | 0.71 | TDP2 (0.47) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL380223 | 0.71 | TDP2 (0.47) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL5917126 | 0.70 | CA1 (0.47) | PNMTADRA2AADRA2BADRA2CTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618906-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | JUVANTIA PHARMA LTD OY (FI) | 1998-04-22 | — | — | EP | disclosed |
| US-5498623-A | MULTISTAGE REACTION FOR HALOGENATION OF COMPOUNDS, NITRATION, REDUCTION AND CONVERSION TO DIAZONIUM SALT THEN HALOGENATION FOR COGNITIVE DISORDERS | ORION-YHTYMA OY (FI) | 1996-03-12 | — | — | US | disclosed |