SCHEMBL8612969

SCHEMBL8612969

COc1nc(F)cc2nc(S(=O)(=O)Nc3c(F)ccc4cccnc34)nn12

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SLC40A1 Q9NP59 9/20 0.43
GLO1 Q04760 2/20 0.41
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
POLB P06746 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8611161 0.91 SLC40A1 (0.42) SLC40A1GLO1MEN1KMT2APOLB
SCHEMBL910274 0.85 GAA (0.42) SLC40A1KMT2A
SCHEMBL8113170 0.79 TSHR (0.39)
SCHEMBL9035985 0.78 SLC40A1 (0.37) SLC40A1GLO1MEN1KMT2APOLB
SCHEMBL8902858 0.78 SMN1; SMN2 (0.35) KMT2A
SCHEMBL8881879 0.77 TSHR (0.34)
SCHEMBL8881103 0.77 HTT (0.35) ALDH1A1
SCHEMBL6999983 0.76 TSHR (0.36) SLC40A1KMT2APOLBALDH1A1
SCHEMBL8848572 0.74 GNRHR (0.34) ALDH1A1
SCHEMBL8113251 0.73 LMNA (0.37) MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998030564-A1 SULFONAMIDE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1998-07-16 WO disclosed