SCHEMBL8113170

SCHEMBL8113170

COc1nc(F)cc2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nn12

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.39
CCR4 P51679 5/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8113251 0.90 LMNA (0.37) TSHR
SCHEMBL910274 0.90 GAA (0.42) TSHRCCR4
Diclosulam SCHEMBL116344 0.89 GNRHR (0.35) TSHRCCR4
SCHEMBL8107570 0.89 SCN1A (0.34) TSHRCCR4
SCHEMBL9535324 0.87 TSHR (0.42) TSHRCCR4
SCHEMBL8848572 0.84 GNRHR (0.34) TSHRCCR4
SCHEMBL7074184 0.83 TSHR (0.34) TSHRCCR4
Diclosulam SCHEMBL2231960 0.83 CA2 (0.33) TSHR
Diclosulam SCHEMBL407709 0.83 CCR4 (0.33) CCR4
SCHEMBL26838562 0.83 CCR4 (0.34) TSHRCCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2598540-B2 1997-04-09 JP claimed
WO-1989011782-A1 ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THE DOW CHEMICAL COMPANY (US) 1989-12-14 WO claimed
EP-0343752-A1 Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates DowElanco (US) 1989-11-29 EP claimed
US-6114580-A N-arylsulfilimine compounds and their use as catalysts in the preparation of N-arylarylsulfonamide compounds DOW AGROSCIENCES LLC (US) 2000-09-05 US disclosed
EP-0888297-B1 N-ARYLSULFILIMINE COMPOUNDS AND THEIR USE AS CATALYSTS IN THE PREPARATION OF N-ARYLARYLSULFONAMIDE COMPOUNDS DOW AGROSCIENCES LLC (US) 2000-08-30 EP disclosed
US-5973148-A N-arylsulfilimine compounds and their use as catalysts in the preparation of N-arylarylsulfonamide compounds DOW AGROSCIENCES LLC (US) 1999-10-26 US disclosed
US-5661189-A SKIN CLEANSING COMPOSITION COMPRISING A SURFACTANT, A PARTICULATE ?BENEFIT? AGENT, A THICKENER AND A VERY SMALL AMOUNT OF SOLID SOAP; MOISTURIZING, CONDITIONING AND PROTECTION ACHIEVED BY LARGE DEPOSITS LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1997-08-26 US disclosed
US-5612307-A CLEANSING AND MOISTURIZING SKIN LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1997-03-18 US disclosed