Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.52 |
| ▸ | LAP3 | P28838 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612042 | 1.00 | FOLH1 (0.52) | FOLH1LAP3CTSKCTSSCTSL | |
| SCHEMBL8613767 | 0.87 | FOLH1 (0.49) | FOLH1LAP3CTSKCTSSCTSL | |
| SCHEMBL8613294 | 0.87 | FOLH1 (0.49) | FOLH1LAP3CTSKCTSSCTSL | |
| SCHEMBL8610880 | 0.84 | FOLH1 (0.61) | FOLH1LAP3CTSKCTSSCTSL | |
| SCHEMBL8610878 | 0.84 | FOLH1 (0.61) | FOLH1LAP3CTSKCTSSCTSL | |
| SCHEMBL8613311 | 0.83 | FOLH1 (0.50) | FOLH1LAP3MMP9MMP8 | |
| SCHEMBL8897466 | 0.79 | CTSK (0.54) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL8897470 | 0.78 | CTSL (0.43) | CTSKCTSSCTSLCTSBALDH1A1 | |
| SCHEMBL17739742 | 0.73 | CTSS (0.37) | CTSKCTSSCTSLCTSBMMP9 | |
| SCHEMBL8897791 | 0.73 | ALDH1A1 (0.60) | FOLH1ALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |