Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.48 |
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSB | P07858 | 5/20 | 0.48 |
| ▸ | CTSL | P07711 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897466 | 0.87 | CTSK (0.54) | CTSKCTSSCTSBCTSLMEN1 | |
| SCHEMBL8896176 | 0.86 | CTSK (0.59) | CTSKCTSSCTSBCTSL | |
| SCHEMBL8895307 | 0.82 | CTSK (0.57) | CTSKCTSSCTSBCTSLMEN1 | |
| SCHEMBL8896567 | 0.82 | CTSK (0.57) | CTSKCTSSCTSBCTSLMEN1 | |
| SCHEMBL8613311 | 0.80 | FOLH1 (0.50) | — | |
| SCHEMBL16867535 | 0.75 | CTSK (0.49) | CTSKCTSBMEN1KMT2A | |
| SCHEMBL16847826 | 0.74 | CTSL (0.54) | CTSKCTSSCTSBCTSLMEN1 | |
| SCHEMBL8898663 | 0.73 | HSP90AA1 (0.54) | CTSKCTSSCTSBCTSLMEN1 | |
| SCHEMBL8612448 | 0.72 | ALDH1A1 (0.56) | CTSKCTSSCTSBCTSLKMT2A | |
| SCHEMBL8895941 | 0.72 | CTSB (0.56) | CTSKCTSSCTSBCTSLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |