SCHEMBL8613353

SCHEMBL8613353

Cc1cc(N(C(=O)c2ccccc2)C(N)=S)c(Cl)cc1N(C(=O)c1ccccc1)C(N)=S

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.35
CTSK P43235 1/20 0.35
TRPM8 Q7Z2W7 3/20 0.35
RAB9A P51151 2/20 0.34
NPC1 O15118 1/20 0.34
PKM P14618 1/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 2/20 0.34
GAA P10253 1/20 0.34
AGTR1 P30556 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
GPBAR1 Q8TDU6 3/20 0.34
KLK1 P06870 2/20 0.33
DEPTOR Q8TB45 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28438210 0.80 ALDH1A1 (0.39) TRPM8RAB9ANPC1PKMALDH1A1
SCHEMBL2022475 0.72 TSHR (0.39) TRPM8RAB9AALDH1A1MAPTGAA
SCHEMBL8613623 0.72 GAA (0.46) CTSLCTSKTRPM8ALDH1A1MAPT
SCHEMBL27687053 0.71 MAPT (0.46) TRPM8RAB9AALDH1A1MAPTGAA
SCHEMBL2762261 0.71 ALDH1A1 (0.50) TRPM8RAB9AALDH1A1MAPTGAA
SCHEMBL27706292 0.71 CES2 (0.46) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL27706288 0.69 SIGMAR1 (0.40) CTSLCTSKRAB9ANPC1ALDH1A1
SCHEMBL2913048 0.67 L3MBTL1 (0.41) TRPM8RAB9ANPC1PKMALDH1A1
SCHEMBL8723486 0.67 KMT2A (0.53) RAB9ANPC1PKMALDH1A1MAPT
SCHEMBL27813922 0.67 SMN1; SMN2 (0.44) RAB9ANPC1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0611754-B1 Dimerized thiourea derivatives, near-infrared absorbents comprising the same, and heat wave shielding materials comprising the same JUJO PAPER CO LTD (JP) 1998-04-22 EP disclosed
US-5723075-A HEAT RESISTANT ABSORBERS WITH RESINS FOR SHIELDS NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1998-03-03 US disclosed
EP-0611754-A1 Dimerized thiourea derivatives, near-infrared absorbents comprising the same, and heat wave shielding materials comprising the same NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1994-08-24 EP disclosed