SCHEMBL8613638

SCHEMBL8613638

CC(C)[C@H](NCCc1ccccc1)C(=O)NC(=O)OC(C)(C)C

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.52
CTSK P43235 4/20 0.50
CTSS P25774 3/20 0.50
NPC1 O15118 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
RAB9A P51151 2/20 0.47
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX12 P18054 1/20 0.47
CTSL P07711 1/20 0.46
CTSB P07858 1/20 0.46
KLK5 Q9Y337 1/20 0.45
CYP2D6 P10635 1/20 0.45
KMT2A Q03164 1/20 0.45
MAPT P10636 1/20 0.45
IDO1 P14902 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8617454 0.90 CA2 (0.51) CA2CTSKCTSSCTSLCTSB
SCHEMBL7309512 0.88 CA12 (0.50) CTSKCTSSCTSLCTSBKLK5
SCHEMBL9229164 0.84 SDCBP (0.48) CA2CTSKCTSSNPC1RAB9A
SCHEMBL8416665 0.84 CA2 (0.72) CA2CTSKCTSSKMT2A
SCHEMBL7314443 0.82 CTSK (0.48) CTSKCTSSCTSLCTSBKLK5
SCHEMBL7313867 0.82 CTSK (0.48) CTSKCTSSCTSLCTSBKLK5
SCHEMBL8613335 0.81 CTSK (0.65) CTSKCTSS
SCHEMBL10448140 0.80 CA2 (0.53) CA2CTSKCTSSCTSLCTSB
SCHEMBL7316663 0.80 CA2 (0.53) CA2CTSKCTSSALDH1A1KLK5
SCHEMBL572740 0.79 IDO1 (0.60) CA2CTSKCTSSNPC1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0838471-A1 PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST SAGAMI CHEMICAL RESEARCH CENTER (JP) 1998-04-29 EP disclosed