SCHEMBL8615041

SCHEMBL8615041

C[SiH](C)C(/C(F)=C(\F)c1ccc(F)cc1)c1ccc(F)c(Oc2ccccc2)c1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PTGER4 P35408 3/20 0.37
PTGER2 P43116 2/20 0.37
PARP10 Q53GL7 1/20 0.35
LPAR1 Q92633 8/20 0.34
LPAR5 Q9H1C0 8/20 0.34
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
SRD5A2 P31213 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
DUT P33316 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8615047 1.00 LMNA (0.38) LMNASMN1; SMN2L3MBTL1PTGER4PTGER2
SCHEMBL8619898 0.92 PTGER4 (0.37) LMNASMN1; SMN2L3MBTL1PTGER4PTGER2
SCHEMBL8615546 0.88 LTA4H (0.40) LMNAL3MBTL1LPAR1LPAR5HTR2A
SCHEMBL8614960 0.85 PTGS1 (0.43) LMNASRD5A2ALDH1A1GAA
SCHEMBL8618670 0.77 PTGS1 (0.42) PTGER4PTGER2SRD5A2
SCHEMBL8622010 0.72 LTA4H (0.47) LMNAL3MBTL1SRD5A2ALDH1A1
SCHEMBL10561616 0.71 LMNA (0.49) LMNAHTR2ASLC6A4DUT
SCHEMBL10549937 0.70 UGT2B7 (0.47) LMNAL3MBTL1HTR2ASLC6A4SRD5A2
SCHEMBL9540375 0.70 UGT2B7 (0.47) LMNAL3MBTL1HTR2ASLC6A4SRD5A2
SCHEMBL10549932 0.70 UGT2B7 (0.47) LMNAL3MBTL1HTR2ASLC6A4SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5710102-A Difluorovinylsilane insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1998-01-20 US disclosed