Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556244 | 0.74 | SIGMAR1 (0.41) | MEN1KMT2AMAPTS1PR1TP53 | |
| SCHEMBL9954933 | 0.70 | DPP4 (0.44) | MEN1KMT2AMAPT | |
| SCHEMBL8615518 | 0.69 | ADRA1A (0.40) | DRD2S1PR1GLAHPGDALDH1A1 | |
| SCHEMBL27777487 | 0.69 | MMP8 (0.42) | MEN1KMT2AMAPT | |
| SCHEMBL15824244 | 0.69 | DPP4 (0.43) | KMT2AMAPTHPGDALDH1A1 | |
| SCHEMBL14999534 | 0.66 | IDO1 (0.38) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL1586715 | 0.66 | TACR1 (0.42) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5146600 | 0.66 | DRD2 (0.71) | DRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL77054 | 0.66 | IDO1 (0.41) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL9232773 | 0.63 | CYP3A4 (0.51) | MEN1KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635496-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-29 | — | — | EP | disclosed |
| US-5464859-A | Alpha adrenergic antagonist | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0635496-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |