Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | RBP1 | P09455 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251629 | 0.87 | ADRA1A (0.32) | ADRA1AKDM4EALDH1A1HPGDS1PR1 | |
| SCHEMBL8616402 | 0.83 | ADRA2A (0.49) | ADRA2ADRD2DRD3 | |
| SCHEMBL7928877 | 0.76 | CYP1A2 (0.42) | ADRA1ARBP1KDM4ES1PR1 | |
| SCHEMBL7917723 | 0.76 | S1PR1 (0.42) | ADRA1ARBP1S1PR1 | |
| SCHEMBL28449241 | 0.71 | ADRA1A (0.38) | ADRA1ARBP1KDM4EALDH1A1HPGD | |
| SCHEMBL28054318 | 0.71 | ADRA1A (0.38) | ADRA1ARBP1KDM4EALDH1A1HPGD | |
| SCHEMBL11010508 | 0.71 | ADRA1A (0.38) | ADRA1ARBP1KDM4EALDH1A1HPGD | |
| SCHEMBL28456745 | 0.70 | KDM4E (0.38) | ADRA1ARBP1KDM4EALDH1A1HPGD | |
| SCHEMBL28456741 | 0.70 | KDM4E (0.38) | ADRA1ARBP1KDM4EALDH1A1HPGD | |
| SCHEMBL8615836 | 0.69 | DRD2 (0.41) | ALDH1A1HPGDGLAS1PR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635496-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-29 | — | — | EP | disclosed |
| US-5464859-A | Alpha adrenergic antagonist | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0635496-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |