Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794997 | 0.79 | HRH3 (0.41) | GPR119POLBHRH3USP30ALDH1A1 | |
| SCHEMBL8621416 | 0.77 | CYP3A4 (0.47) | POLBGRM5ALDH1A1L3MBTL1 | |
| SCHEMBL4730546 | 0.75 | GPR119 (0.65) | GPR119HRH3ALDH1A1 | |
| SCHEMBL19903210 | 0.73 | ALDH1A1 (0.46) | GPR119POLBHRH3ALDH1A1 | |
| SCHEMBL8619492 | 0.72 | ALDH1A1 (0.50) | POLBALDH1A1 | |
| SCHEMBL4768721 | 0.72 | GPR119 (0.62) | GPR119POLBUSP30GRM5 | |
| SCHEMBL3804900 | 0.70 | GPR119 (0.60) | GPR119POLBUSP30GRM5 | |
| SCHEMBL8619009 | 0.69 | KDM2B (0.47) | POLBHRH3L3MBTL1 | |
| SCHEMBL4351146 | 0.68 | LMNA (0.44) | GPR119POLBELANEALDH1A1 | |
| SCHEMBL4480416 | 0.68 | GPR119 (0.57) | GPR119POLBUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |