Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066590 | 0.86 | LMNA (0.60) | HPSEPRMT5NUDT1KMT2ALMNA | |
| SCHEMBL1367313 | 0.85 | PRMT5 (0.65) | PRMT5KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL27593194 | 0.82 | ALDH1A1 (0.49) | HPSEPRMT5NUDT1KMT2ALMNA | |
| SCHEMBL12807020 | 0.82 | HPSE (0.48) | HPSEPRMT5NUDT1KMT2ALMNA | |
| SCHEMBL4316866 | 0.82 | ALDH1A1 (0.67) | PRMT5KMT2ADAGLAKDM4ENPC1 | |
| SCHEMBL29623058 | 0.76 | DAGLA (0.56) | HPSEPRMT5NUDT1KMT2ALMNA | |
| SCHEMBL9239194 | 0.76 | NUDT1 (0.59) | HPSENUDT1KMT2AKDM4ECYP1A2 | |
| SCHEMBL2291563 | 0.76 | DAGLA (0.56) | HPSEPRMT5NUDT1KMT2ALMNA | |
| SCHEMBL31404329 | 0.76 | NUDT1 (0.59) | HPSENUDT1KMT2AKDM4ECYP1A2 | |
| SCHEMBL204726 | 0.75 | NPC1 (0.73) | KMT2ALMNAKDM4ENPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |