Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.59 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 6/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31404329 | 1.00 | NUDT1 (0.59) | NUDT1METAP1METAP2PDE5AAURKA | |
| Water SCHEMBL31266989 | 0.77 | NUDT1 (0.96) | NUDT1METAP1METAP2PDE5AAURKA | |
| Water SCHEMBL30578580 | 0.77 | NUDT1 (0.96) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL861789 | 0.76 | HPSE (0.52) | NUDT1METAP1METAP2PDE5AHPSE | |
| SCHEMBL5385517 | 0.76 | NUDT1 (0.49) | NUDT1METAP1METAP2PDE5ATP53 | |
| SCHEMBL29066590 | 0.75 | LMNA (0.60) | NUDT1PDE5AHPSEKDM4EFGFR1 | |
| SCHEMBL30413155 | 0.75 | NUDT1 (1.00) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL42319 | 0.75 | NUDT1 (1.00) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL1170747 | 0.74 | METAP1 (0.72) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL3997802 | 0.74 | PDE5A (0.50) | NUDT1METAP1METAP2PDE5AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220380341-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-12-01 | — | — | US | disclosed |
| WO-2020081856-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-0646579-A1 | Ketonic indane derivatives and heterocyclic analysis and their use in therapy | LABORATOIRE INNOTHERA Société Anonyme (FR) | 1995-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220380341-A1 | INHIBITORS OF HIV-1 NEF FOR THE TREATMENT OF HIV DISEASE | NAT1, CXCR4, HAX1 | NUDT1 422/4885METAP1 1809/4885METAP2 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.