Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439618 | 0.93 | GSK3A (0.43) | GSK3BGSK3ASIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8772475 | 0.92 | FAAH (0.42) | GSK3BGSK3ASIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8772495 | 0.88 | GSK3A (0.41) | GSK3BGSK3ASIGMAR1L3MBTL1MEN1 | |
| SCHEMBL8772398 | 0.87 | GSK3A (0.39) | GSK3BGSK3ASIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8772402 | 0.87 | HTR2A (0.43) | GSK3BGSK3ASIGMAR1MEN1CYP1A2 | |
| SCHEMBL8592992 | 0.83 | TRPV1 (0.43) | L3MBTL1TSHRKMT2A | |
| SCHEMBL8550924 | 0.83 | TRPV1 (0.43) | L3MBTL1TSHRKMT2A | |
| SCHEMBL8772523 | 0.83 | HCRTR1 (0.43) | GSK3BGSK3AL3MBTL1MGLLMEN1 | |
| SCHEMBL8555803 | 0.83 | HRH3 (0.41) | SIGMAR1 | |
| SCHEMBL8109827 | 0.78 | FAAH (0.43) | GSK3BGSK3ASIGMAR1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865429-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021676-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-19 | — | — | WO | disclosed |