Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620443 | 1.00 | KMT2A (0.62) | KMT2AALDH1A1CYP2A6ALDH1A3PARP10 | |
| SCHEMBL4643258 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1CYP2A6ALDH1A3PARP10 | |
| SCHEMBL25950417 | 0.83 | ALDH1A1 (0.53) | KMT2AALDH1A1CYP2A6ALDH1A3PARP10 | |
| SCHEMBL20577757 | 0.82 | HSD17B10 (0.46) | KMT2AMAPTMEN1CA2LMNA | |
| SCHEMBL15985197 | 0.80 | KMT2A (0.54) | KMT2AMAPTKDM4EMEN1LMNA | |
| SCHEMBL28711842 | 0.80 | LMNA (0.57) | KMT2AALDH1A1MEN1CA2LMNA | |
| SCHEMBL5176450 | 0.80 | ELANE (0.46) | KMT2AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL10694037 | 0.80 | ELANE (0.46) | KMT2AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL27464290 | 0.80 | LMNA (0.57) | KMT2AALDH1A1MEN1CA2LMNA | |
| SCHEMBL10694032 | 0.80 | CA2 (0.41) | KMT2AALDH1A1MAPTMEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690047-B1 | Substituted phenyl 4-[(E)-alk-2-enoyloxy] benzoates | MERCK PATENT GMBH (DE) | 1998-05-20 | — | — | EP | disclosed |
| US-5484551-A | Substituted phenyl 4-[(E)-alk-2-enoyloxy]benzoates | HOFFMANN-LA ROCHE INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0690047-A1 | Substituted phenyl 4-(E)-alk-2-enoyloxy benzoates | F. Hoffmann-La Roche AG (CH) | 1996-01-03 | — | — | EP | disclosed |