Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617883 | 0.78 | ALDH1A1 (0.44) | CRHBPCRHR2TSHRCYP3A4NCEH1 | |
| SCHEMBL8618849 | 0.78 | TSHR (0.53) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL7358973 | 0.77 | HSP90AA1 (0.49) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL8623600 | 0.76 | NCEH1 (0.37) | TSHRCYP3A4NCEH1LMNAALDH1A1 | |
| SCHEMBL8622301 | 0.73 | HSP90AA1 (0.45) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL9982623 | 0.72 | MERTK (0.48) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL31388678 | 0.71 | TSHR (0.55) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL7170274 | 0.71 | TSHR (0.55) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| SCHEMBL12047547 | 0.71 | TSHR (0.54) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 | |
| Phosphonic Acid SCHEMBL27293071 | 0.70 | TSHR (0.54) | HSP90AA1CRHBPCRHR2TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710138-A | Benzo f!quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0696289-B1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| WO-1994025470-A1 | BENZO[F]QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |