Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918142 | 0.80 | BACE1 (0.33) | — | |
| SCHEMBL14123572 | 0.78 | ADRA2A (0.52) | ADRA2ADRD2DRD3CHRM2CHRM1 | |
| SCHEMBL8616402 | 0.75 | ADRA2A (0.49) | ADRA2ADRD2DRD3CHRM2CHRM1 | |
| SCHEMBL8553587 | 0.74 | BACE1 (0.39) | ADRA2A | |
| Hydrochloric Acid SCHEMBL9179624 | 0.73 | BACE1 (0.38) | ADRA2A | |
| SCHEMBL4599810 | 0.72 | ADRA2A (0.47) | ADRA2ADRD2DRD3CHRM2CHRM1 | |
| SCHEMBL19469472 | 0.71 | HTR5A (0.41) | ADRA2ADRD2DRD3DRD1DRD5 | |
| SCHEMBL10976492 | 0.71 | ADRA2A (0.48) | ADRA2ADRD2DRD3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL10914162 | 0.70 | MTNR1A (0.45) | ADRA2ADRD2DRD3DRD4MTNR1A | |
| SCHEMBL12789698 | 0.70 | ADRA2A (0.50) | ADRA2ADRD2DRD3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635496-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-29 | — | — | EP | disclosed |
| US-5464859-A | Alpha adrenergic antagonist | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0635496-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |