Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612657 | 0.81 | NOTUM (0.47) | TSHRPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL8658481 | 0.76 | HTR1A (0.55) | HTR2APOLBDRD1HRH2HTR2C | |
| SCHEMBL8617695 | 0.75 | NOTUM (0.43) | ALDH1A1HPGDKDM4ERECQLNOTUM | |
| SCHEMBL8616789 | 0.73 | SLC6A4 (0.43) | HTR2ADRD2HTR7HTR6DRD1 | |
| SCHEMBL21469289 | 0.72 | NOTUM (0.54) | TSHRPOLBALDH1A1KDM4ENOTUM | |
| SCHEMBL8148793 | 0.68 | NOTUM (0.54) | ALDH1A1HPGDKDM4ERECQLNOTUM | |
| SCHEMBL21469189 | 0.68 | NOTUM (0.58) | HTR2AHTR2CALDH1A1HPGDKDM4E | |
| SCHEMBL8615022 | 0.68 | ALDH1A1 (0.47) | HTR2ADRD1HRH2HTR2COPRK1 | |
| SCHEMBL15640026 | 0.67 | NOTUM (0.59) | ALDH1A1HPGDKDM4ENOTUMKMT2A | |
| SCHEMBL8129693 | 0.67 | SLC2A1 (0.49) | TSHRALDH1A1HPGDKDM4ENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |