Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMD1 | P17707 | 8/20 | 0.52 |
| ▸ | HSPA8 | P11142 | 3/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621046 | 1.00 | AMD1 (0.52) | AMD1HSPA8HSPA5RXFP1HSD17B10 | |
| SCHEMBL8623937 | 0.88 | NADK (0.53) | HSPA8HSPA5RXFP1HSD17B10ADORA3 | |
| SCHEMBL8623943 | 0.88 | NADK (0.53) | HSPA8HSPA5RXFP1HSD17B10ADORA3 | |
| SCHEMBL14034324 | 0.87 | AMD1 (0.55) | AMD1HSPA8HSPA5RXFP1HSD17B10 | |
| Lodenosine SCHEMBL30998176 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 | |
| Lodenosine SCHEMBL29421139 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 | |
| Lodenosine SCHEMBL8451244 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 | |
| Lodenosine SCHEMBL3483 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 | |
| Lodenosine SCHEMBL22869478 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 | |
| Lodenosine SCHEMBL29329162 | 0.79 | EGFR (0.61) | GAPDHSLC28A2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817799-A | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0540686-B1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5336764-A | 2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1992001700-A1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) | 1992-02-06 | — | — | WO | disclosed |