Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NADK | O95544 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.47 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.47 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623937 | 1.00 | NADK (0.53) | NADKADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3704527 | 0.88 | NADK (0.57) | NADKADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3701954 | 0.88 | NADK (0.57) | NADKADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL8621046 | 0.88 | AMD1 (0.52) | ADORA3HSPA5HSPA8RXFP1HSD17B10 | |
| SCHEMBL8621042 | 0.88 | AMD1 (0.52) | ADORA3HSPA5HSPA8RXFP1HSD17B10 | |
| SCHEMBL9698117 | 0.83 | NADK (0.44) | NADKADORA2AADORA1ADORA2BADORA3 | |
| Lodenosine SCHEMBL22869478 | 0.78 | EGFR (0.61) | ADORA2AADORA1ADORA2BADORA3 | |
| Lodenosine SCHEMBL30998176 | 0.78 | EGFR (0.61) | ADORA2AADORA1ADORA2BADORA3 | |
| Lodenosine SCHEMBL3483 | 0.78 | EGFR (0.61) | ADORA2AADORA1ADORA2BADORA3 | |
| Lodenosine SCHEMBL8451244 | 0.78 | EGFR (0.61) | ADORA2AADORA1ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817799-A | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0540686-B1 | 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES | US COMMERCE (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5336764-A | 2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-08-09 | — | — | US | disclosed |