Lodenosine

Lodenosine

SCHEMBL3483

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)C[C@H]1F

nearest known ligand 0.61

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.61
ERBB2 P04626 1/20 0.61
ADORA3 P0DMS8 4/20 0.59
ADORA2B P29275 3/20 0.59
ADORA2A P29274 2/20 0.59
ADORA1 P30542 2/20 0.59
PI4KA P42356 2/20 0.59
PI4K2B Q8TCG2 2/20 0.59
PI4K2A Q9BTU6 2/20 0.59
PI4KB Q9UBF8 2/20 0.59
DPP4 P27487 1/20 0.59
MEN1 O00255 1/20 0.59
SLC28A1 O00337 1/20 0.59
MAP3K7 O43318 1/20 0.59
SLC28A2 O43868 1/20 0.59
GAPDH P04406 1/20 0.59
MAPK1 P28482 1/20 0.59
STAT6 P42226 1/20 0.59
KMT2A Q03164 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lodenosine SCHEMBL3482 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL16670086 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL29663669 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL29831913 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL8451244 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL29421139 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL29329162 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL30998176 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL22869478 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A
Lodenosine SCHEMBL97908 1.00 EGFR (0.61) EGFRERBB2ADORA3ADORA2BADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7741372-B2 Guanylhydrazones useful for treating diseases associated with T cell activation CYTOKINE PHARMASCIENCES, INC. (US) 2010-06-22 US claimed
US-20100080830-A1 SYSTEMIC DELIVERY OF ANTIVIRAL AGENTS PSIVIDA INC. (US) 2010-04-01 US claimed
US-20060154892-A1 Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis LORI FRANCO 2006-07-13 US claimed
US-20040115268-A1 Systemic delivery of antiviral agents CONTROL DELIVERY SYSTEMS, INC. 2004-06-17 US claimed
WO-2004043435-A2 SYSTEMIC DELIVERY OF ANTIVIRAL AGENTS CONTROL DELIVERY SYSTEMS, INC. (US) 2004-05-27 WO claimed
US-6194390-B1 ADMINISTERING HYDROXYUREA AND A 2'-FLUOROPURINE-DIDEOXY-NUCLEOSIDE SELECTED FROM THE GROUP OF 2'-FLUORO-2',3'-DIDE-OXYADENOSINE,-DIDEOXYINOSINE, AND -DIDEOXYGUANOSINE WITH A CARRIER OR EXCIPIENT; VIRICIDES; RETROVIRUSES; PLANT VIRUSES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2001-02-27 US claimed
WO-1998038202-A1 ANTIVIRAL PHOSPHONATE PRODRUGS OF NUCLEOSIDES AND NUCLEOSIDE ANALOGUES DANA-FARBER CANCER INSTITUTE (US) 1998-09-03 WO claimed
EP-0287313-B1 Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus US COMMERCE (US) 1995-01-04 EP claimed
EP-0464137-A4 INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES 1992-01-15 EP claimed
EP-0464137-A1 INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES ONCOGEN LIMITED PARTNERSHIP (US) 1992-01-08 EP claimed
EP-0428109-A2 Deoxyfluoronucleoside process Bristol-Myers Squibb Company (US) 1991-05-22 EP claimed
WO-1990011081-A1 INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES ONCOGEN LIMITED PARTNERSHIP (US) 1990-10-04 WO claimed
US-20250313905-A1 METHODS AND COMPOSITIONS FOR IMPROVED PSYCHOLOGICAL AND RESILIENCE MEASURES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-10-09 US disclosed
US-12404304-B1 Telomerase reverse transcriptase (TERT) expression enhancing compounds and methods for using the same SIERRA SCIENCES, LLC (US) 2025-09-02 US disclosed
US-12364717-B2 Compositions and methods for inhibiting seizures THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-07-22 US disclosed
US-20250179122-A1 Telomerase Reverse Transcriptase (TERT) Expression Enhancing Compounds and Methods for Using the Same SIERRA SCIENCES, LLC 2025-06-05 US disclosed
EP-0464137-A1 INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES ONCOGEN LIMITED PARTNERSHIP (US) 1992-01-08 EP disclosed
WO-1991019726-A1 ETHER LIPID-NUCLEOSIDE COVALENT CONJUGATES WAKE FOREST UNIVERSITY (US) 1991-12-26 WO disclosed
EP-0428109-A2 Deoxyfluoronucleoside process Bristol-Myers Squibb Company (US) 1991-05-22 EP disclosed
WO-1990011081-A1 INHIBITION OF HIV USING SYNERGISTIC COMBINATIONS OF NUCLEOSIDE DERIVATIVES ONCOGEN LIMITED PARTNERSHIP (US) 1990-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179122-A1 Telomerase Reverse Transcriptase (TERT) Expression Enhancing Compounds and Methods for Using the Same TERT, RNGTT, TERF2 EGFR 3271/4885ERBB2 3820/4885ADORA3 4797/4885
US-20100080830-A1 SYSTEMIC DELIVERY OF ANTIVIRAL AGENTS HAVCR2, MAVS, PGF EGFR 3385/4885ERBB2 3602/4885ADORA3 84/4885
US-12404304-B1 Telomerase reverse transcriptase (TERT) expression enhancing compounds and methods for using the same TERT, TELO2, POT1 EGFR 2775/4885ERBB2 2690/4885ADORA3 4029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.