Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL8622087 | 1.00 | HIF1A (0.49) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7543562 | 0.91 | HIF1A (0.50) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8369647 | 0.91 | HIF1A (0.50) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8369646 | 0.91 | HIF1A (0.50) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7535610 | 0.90 | HIF1A (0.62) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8372755 | 0.90 | HIF1A (0.48) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8624128 | 0.90 | HIF1A (0.48) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8619665 | 0.90 | HIF1A (0.62) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7541196 | 0.90 | HIF1A (0.49) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8372754 | 0.90 | HIF1A (0.48) | HIF1ASMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658541-B1 | PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE | SHIONOGI & CO (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5510506-A | Process for producing carboxylic acid derivatives | SHIONOGI & CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0658541-A1 | PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1995-06-21 | — | — | EP | disclosed |